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Diazepam was patented in 1959 by Hoffmann-La Roche and put out there officially in 1963. At time, diazepam was a clear advancement to the prior generation of hypnotic anxiolytics — the barbiturates. The effects were being also deemed an improvement on its progenitor, Librium.The alpha subunit has several isoforms, which dictate a BZD’s effects